Document Detail

Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities of N-acylsulfonamides using silica sulfuric acid as an efficient catalyst under both solvent-free and heterogeneous conditions.
MedLine Citation:
PMID:  18439830     Owner:  NLM     Status:  MEDLINE    
Silica sulfuric acid catalyzes efficiently the reaction of sulfonamides with both carboxylic acid anhydrides and chlorides under solvent-free and heterogeneous conditions. All the reactions were done at room temperature and the N-acylsulfonamides were obtained with high yields and purity via an easy work-up procedure. This method is attractive and is in a close agreement with green chemistry. These compounds were also investigated for antibacterial activity, including Gram-positive cocci and Gram-negative bacilli, and carbonic anhydrase II inhibitory activity.
Ahmad Reza Massah; Hadi Adibi; Reza Khodarahmi; Ramin Abiri; Mohammad Bagher Majnooni; Sherita Shahidi; Beheshteh Asadi; Masomeh Mehrabi; Mohammad Ali Zolfigol
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-11
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  16     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  5465-72     Citation Subset:  IM    
Department of Chemistry, Islamic Azad University, Shahreza Branch, Shahreza 86145-311, Islamic Republic of Iran.
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MeSH Terms
Anti-Bacterial Agents / chemical synthesis*,  chemistry,  pharmacology*
Carbonic Anhydrase II / antagonists & inhibitors*
Carbonic Anhydrase Inhibitors / chemical synthesis*,  chemistry,  pharmacology*
Gram-Negative Bacteria / drug effects
Gram-Positive Cocci / drug effects
Microbial Sensitivity Tests
Molecular Structure
Silicon Dioxide / chemistry
Structure-Activity Relationship
Sulfonamides / chemical synthesis*,  chemistry,  pharmacology*
Sulfuric Acids / chemistry
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Carbonic Anhydrase Inhibitors; 0/Sulfonamides; 0/Sulfuric Acids; 7631-86-9/Silicon Dioxide; EC 4.2.1.-/Carbonic Anhydrase II

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