| Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities of N-acylsulfonamides using silica sulfuric acid as an efficient catalyst under both solvent-free and heterogeneous conditions. | |
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MedLine Citation:
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PMID: 18439830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Silica sulfuric acid catalyzes efficiently the reaction of sulfonamides with both carboxylic acid anhydrides and chlorides under solvent-free and heterogeneous conditions. All the reactions were done at room temperature and the N-acylsulfonamides were obtained with high yields and purity via an easy work-up procedure. This method is attractive and is in a close agreement with green chemistry. These compounds were also investigated for antibacterial activity, including Gram-positive cocci and Gram-negative bacilli, and carbonic anhydrase II inhibitory activity. |
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Authors:
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Ahmad Reza Massah; Hadi Adibi; Reza Khodarahmi; Ramin Abiri; Mohammad Bagher Majnooni; Sherita Shahidi; Beheshteh Asadi; Masomeh Mehrabi; Mohammad Ali Zolfigol |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-11 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 16 ISSN: 1464-3391 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-26 Completed Date: 2008-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 5465-72 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Islamic Azad University, Shahreza Branch, Shahreza 86145-311, Islamic Republic of Iran. massah@iaush.ac.ir |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemical synthesis*,
chemistry,
pharmacology* Carbonic Anhydrase II / antagonists & inhibitors* Carbonic Anhydrase Inhibitors / chemical synthesis*, chemistry, pharmacology* Catalysis Gram-Negative Bacteria / drug effects Gram-Positive Cocci / drug effects Microbial Sensitivity Tests Molecular Structure Silicon Dioxide / chemistry Stereoisomerism Structure-Activity Relationship Sulfonamides / chemical synthesis*, chemistry, pharmacology* Sulfuric Acids / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Carbonic Anhydrase Inhibitors; 0/Sulfonamides; 0/Sulfuric Acids; 7631-86-9/Silicon Dioxide; EC 4.2.1.-/Carbonic Anhydrase II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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