Document Detail

Synthesis and in vitro PDT activity of miscellaneous porphyrins with amino acid and uracil.
MedLine Citation:
PMID:  18439834     Owner:  NLM     Status:  MEDLINE    
The synthesis of a series of modularized porphyrins bearing bioactive molecule is described. Starting with meso-tetraphenylporphyrin, the compounds with two nitro functional groups were synthesized via regiospecific nitration reaction. After reduction to the amino group and subsequent coupling with l-phenylalanine or 1-carboxylmethyl-5-fluorouracil (5-Fu acid), the functionalized porphyrins were metallized with Co(II) or Mn(II) to form miscellaneous porphyrins in good yields. The spectra of all the porphyrins were furnished. In vitro photodynamic therapy of the porphyrins against Ec9706 cell line was evaluated by standard cytotoxicity assays.
Shi Weimin; Zhang Gen; Dai Guifu; Zhang Yunxiao; Zhao Jin; Tao Jingchao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-30
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  16     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  5665-71     Citation Subset:  IM    
Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China.
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MeSH Terms
Cell Line, Tumor
Cell Proliferation / drug effects
Cobalt / chemistry
Drug Screening Assays, Antitumor
Esophageal Neoplasms / drug therapy*
Manganese / chemistry
Molecular Structure
Organometallic Compounds / chemical synthesis*,  pharmacology*,  radiation effects
Phenylalanine / chemistry*
Phloroglucinol / analogs & derivatives*,  chemistry,  isolation & purification,  pharmacology
Porphyrins / chemistry*
Structure-Activity Relationship
Ultraviolet Rays
Reg. No./Substance:
0/Organometallic Compounds; 0/Porphyrins; 0/petiolin A; 108-73-6/Phloroglucinol; 63-91-2/Phenylalanine; 7439-96-5/Manganese; 7440-48-4/Cobalt

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