Document Detail


Synthesis and in Vitro cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10-diones.
MedLine Citation:
PMID:  20512462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of 2-alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10-diones (4a-f) was synthesized and their in vitro cytotoxic activities were evaluated against six human cancer cell lines (HCT15, SK-OV-3, SNB19, A549, MCF7 and MCF7/ADR). They all appeared to be less potent than doxorubicin against all doxorubicin sensitive human cancer cell lines tested. However, these compounds retained considerable cytotoxic activity against the doxorubicin-resistant cell line MCF7/ADR, implying their therapeutic potential to treat doxorubicin-resistant tumors. The most active compound 4c was equipotent with doxorubicin against HCT15 cell line.
Authors:
Jae-Hwan Kwak; Kwon Namgoong; Jae-Kyung Jung; Sang-Bae Han; Jungsook Cho; Hwan-Mook Kim; Song-Gyu Park; Kiho Lee; Jong Soon Kang; Heesoon Lee
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-29
Journal Detail:
Title:  Archives of pharmacal research     Volume:  33     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  663-7     Citation Subset:  IM    
Affiliation:
Chungbuk National University, Cheongju, Korea.
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MeSH Terms
Descriptor/Qualifier:
Anthracenes / chemical synthesis*,  pharmacology*
Antineoplastic Agents / chemical synthesis*,  pharmacology*
Cell Line, Tumor
Cell Survival / drug effects*
Doxorubicin / pharmacology
Drug Resistance, Neoplasm / drug effects
Drug Screening Assays, Antitumor / methods
Humans
Molecular Structure
Quantitative Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Anthracenes; 0/Antineoplastic Agents; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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