| Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. | |
| | |
MedLine Citation:
|
PMID: 16784848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Several 9-benzyl adenine derivatives bearing various substituted amines at the 8-position have been prepared and evaluated for interferon induction in peripheral blood mononuclear cells (PBMC) from healthy human donors. The 8-bromoadenine derivative 5 was used as a versatile intermediate for all substitutions. The most active 8-substituted amino compound was found to be the 8-morpholinoethylamino derivative 19 which had an EC(50) in the submicromolar range. |
| | |
Authors:
|
Guangyi Jin; Christina C N Wu; Rommel I Tawatao; Michael Chan; Dennis A Carson; Howard B Cottam |
Related Documents
:
|
20309908 - The configuration, solvatochromism and metallo-responses of two novel cyano-containing ... 18830978 - Efficient synthesis of chromone and flavonoid derivatives with diverse heterocyclic units. 16119928 - Reactions of (trialkylsilyl)vinylketenes with lithium ynolates: a new benzannulation st... 19193048 - Diverse functionalization of corannulene: easy access to pentagonal superstructure. 23618308 - Aminoalkyl functionalization of dextran for coupling of bioactive molecules and nanostr... 6411808 - A standardized monitor for the control of ethylene oxide sterilization cycles. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-06-19 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: 16 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-07-31 Completed Date: 2006-10-16 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
|
Languages: eng Pagination: 4559-63 Citation Subset: IM |
Affiliation:
|
Moores Cancer Center, University of California, San Diego, La Jolla, 92093-0820, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenine
/
analogs & derivatives*,
chemical synthesis,
chemistry,
pharmacology Amination Humans Leukocytes / drug effects Molecular Structure Structure-Activity Relationship Toll-Like Receptor 7 / agonists*, immunology* |
| Grant Support | |
ID/Acronym/Agency:
|
AI56453/AI/NIAID NIH HHS; AI57436/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Toll-Like Receptor 7; 4261-14-7/9-benzyladenine; 73-24-5/Adenine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Design, microwave-assisted synthesis, and spasmolytic activity of 2-(alkyloxyaryl)-1H-benzimidazole ...
Next Document: Identification of a lead pharmacophore for the development of potent nuclear receptor modulators as ...