Document Detail


Synthesis and hypoglycemic activity of some new flavone derivatives. 3rd communication: 3'-flavonyl-2,4-thiazolidinediones.
MedLine Citation:
PMID:  10965419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new series of 3'-flavonyl-2,4-thiazolidinedione, 2,4-imidazolidinedione and 2-thiohydantoin derivatives (1-10) were synthesized and their chemical structures have been elucidated by various spectral data. The prepared compounds were tested for their insulinotropic effects in INS-1 cells. Inhibitory effects were observed for compounds 1 and 2. In contrast compounds 4, 7 and 8 were able to increase insulin release compared with glibenclamide.
Authors:
O Bozdağ; E J Verspohl; R Ertan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  50     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-21     Completed Date:  2000-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  626-30     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Flavonoids / chemical synthesis*,  pharmacology
Glucose / pharmacology
Hypoglycemic Agents / chemical synthesis*,  pharmacology
Insulin / metabolism
Rats
Swine
Chemical
Reg. No./Substance:
0/Flavonoids; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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