| Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling. | |
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MedLine Citation:
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PMID: 11695625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An improved synthesis of hydroxylated polychlorinated biphenyls (PCBs) which are structurally related to the major hydroxy PCB congeners identified in human plasma is described. The coupling of (chlorinated) aryl boronic acids with bromochloro anisoles using the standard conditions of the Suzuki coupling gave the desired hydroxylated PCB metabolites in good to excellent yields. The approach offers the advantage of high selectivity and good yields compared to conventional methods such as the Cadogan reaction and allows the use of less toxic starting materials. |
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Authors:
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H J Lehmler; L W Robertson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Chemosphere Volume: 45 ISSN: 0045-6535 ISO Abbreviation: Chemosphere Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-11-06 Completed Date: 2002-02-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0320657 Medline TA: Chemosphere Country: England |
Other Details:
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Languages: eng Pagination: 1119-27 Citation Subset: IM |
Affiliation:
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Graduate Center for Toxicology, Chandler Medical Center, University of Kentucky, Lexington 40536-0305, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anisoles
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chemistry Boronic Acids / chemistry Environmental Pollutants / analysis* Hydroxylation Polychlorinated Biphenyls / chemical synthesis*, chemistry |
| Grant Support | |
ID/Acronym/Agency:
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P42 ES 07380/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anisoles; 0/Boronic Acids; 0/Environmental Pollutants; 0/Polychlorinated Biphenyls |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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