Document Detail

MedLine Citation:
PMID:  3306344     Owner:  NLM     Status:  MEDLINE    
Aminoacyl tRNA synthetases, by means of a back reaction, are able to synthesize certain 5', 5"'-P1, P4-bisnucleoside tetraphosphates of biological importance, such as Ap4A. Here it is shown that HisRS and TrpRS (Bacillus stearothermophilus) and AlaRS (E. coli) also synthesize the hybrid compounds Ap4G, Ap4C, and Ap4U. GlnRS (E. coli) is unable to synthesize any of the above compounds. AlaRS synthesizes Ap4U very poorly, and Ap4C and Ap4G almost as effectively as Ap4A. HisRS and TrpRS synthesize Ap4G, Ap4U and Ap3U quite effectively, and Ap4C very poorly. The fact that hybrid bisnucleoside tetraphosphates can be made by the same enzymes, and at rates comparable to Ap4A, suggests that these compounds may also occur in vivo.
T W Traut
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  75     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-10-22     Completed Date:  1987-10-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  15-21     Citation Subset:  IM    
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MeSH Terms
Adenine Nucleotides / biosynthesis*
Amino Acyl-tRNA Synthetases / metabolism*
Cytidine / analogs & derivatives,  biosynthesis
Dinucleoside Phosphates*
Escherichia coli / enzymology
Geobacillus stearothermophilus / enzymology
Guanosine / analogs & derivatives,  biosynthesis
Oligoribonucleotides / biosynthesis*
Uridine / analogs & derivatives,  biosynthesis
Reg. No./Substance:
0/Adenine Nucleotides; 0/Dinucleoside Phosphates; 0/Oligoribonucleotides; 0/adenosine 5'-P(1)-tetraphosphate-P(4)-5'''-guanosine; 10527-48-7/adenosine(5')tetraphosphate uridine; 118-00-3/Guanosine; 30632-06-5/adenosine 5'-P(1)-triphosphate-P(3)-5'''-uridine; 5542-28-9/diadenosine tetraphosphate; 58-96-8/Uridine; 65-46-3/Cytidine; 83008-69-9/adenosine 5' P(1)-tetraphosphate-P(4)-5'''-cytidine; EC 6.1.1.-/Amino Acyl-tRNA Synthetases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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