Document Detail


Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.
MedLine Citation:
PMID:  19914836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.
Authors:
Igor Beseda; Laszlo Czollner; Priti S Shah; Rupesh Khunt; Rawindra Gaware; Paul Kosma; Christian Stanetty; Maria Carmen Del Ruiz-Ruiz; Hassan Amer; Kurt Mereiter; Thierry Da Cunha; Alex Odermatt; Dirk Classen-Houben; Ulrich Jordis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-23
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  18     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  433-54     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Inst. Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna 1060, Austria.
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MeSH Terms
Descriptor/Qualifier:
11-beta-Hydroxysteroid Dehydrogenases / antagonists & inhibitors*,  metabolism*
Crystallography, X-Ray
Glycyrrhetinic Acid / analogs & derivatives*,  chemical synthesis,  pharmacology*
Humans
Metabolic Diseases / drug therapy*
Models, Molecular
Chemical
Reg. No./Substance:
471-53-4/Glycyrrhetinic Acid; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenases

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