| Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases. | |
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MedLine Citation:
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PMID: 19914836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed. |
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Authors:
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Igor Beseda; Laszlo Czollner; Priti S Shah; Rupesh Khunt; Rawindra Gaware; Paul Kosma; Christian Stanetty; Maria Carmen Del Ruiz-Ruiz; Hassan Amer; Kurt Mereiter; Thierry Da Cunha; Alex Odermatt; Dirk Classen-Houben; Ulrich Jordis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-23 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 18 ISSN: 1464-3391 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 433-54 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Inst. Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna 1060, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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11-beta-Hydroxysteroid Dehydrogenases
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antagonists & inhibitors*,
metabolism* Crystallography, X-Ray Glycyrrhetinic Acid / analogs & derivatives*, chemical synthesis, pharmacology* Humans Metabolic Diseases / drug therapy* Models, Molecular |
| Chemical | |
Reg. No./Substance:
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471-53-4/Glycyrrhetinic Acid; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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