Document Detail


Synthesis of glycosylated 5-hydroxylysine, an important amino acid present in collagen-like proteins such as adiponectin.
MedLine Citation:
PMID:  22218394     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The synthesis of naturally occurring glycosylated (2S,5R)-hydroxylysine still remains a challenge. This perspective highlights the importance of this post-translationally modified amino acid residue in the observed bioactivity of collagen and related collagen-like proteins such as adiponectin, an important target for the treatment of type II diabetes. Strategies employed to date for the syntheses of (2S,5R)-hydroxylysine and the methods to effect glycosylation of this modified amino acid are also summarized herein.
Authors:
Katherine R Herbert; Geoffrey M Williams; Garth J S Cooper; Margaret A Brimble
Related Documents :
8409774 - Suppression of autoimmune disease by dietary n-3 fatty acids.
9890614 - Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docos...
19367764 - Functional expression of a humanized gene for an omega-3 fatty acid desaturase from sca...
18614744 - Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myoc...
268284 - Amino acid control of stable rna synthesis in friend leukemia cells in relation to intr...
11679874 - Citric acid ingestion: a life-threatening cause of metabolic acidosis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-4
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland, 1142, New Zealand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  AAV-mediated gene transfer of human pigment epithelium-derived factor inhibits Lewis lung carcinoma ...
Next Document:  Administration of biotin prevents the development of insulin resistance in the skeletal muscles of O...