Document Detail


Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery.
MedLine Citation:
PMID:  21641587     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A class of glycolipopeptides for use as building blocks for a new type of dynamic combinatorial library is reported. The members of the library consist of a variable carbohydrate moiety, coded amino acids, and lipoamino acids in order to convert them into amphiphiles. Glycolipopeptidic amphiphiles interact through non-covalent bonding when mixed together in aqueous phase and form micelles in dynamic close-packed fluid mosaic arrays. The head groups of amphiphiles are exposed on the micelle surface, providing entities which could be screened in biological assays to find the most potent combination of building blocks in order to identify new bioactive carbohydrate ligands.
Authors:
Zyta M Ziora; Norbert Wimmer; Roger New; Mariusz Skwarczynski; Istvan Toth
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-15
Journal Detail:
Title:  Carbohydrate research     Volume:  -     ISSN:  1873-426X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043535     Medline TA:  Carbohydr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
The University of Queensland, School of Chemistry and Molecular Biosciences, Brisbane, Qld 4072, Australia; The University of Queensland, Centre for Integrated Preclinical Drug Development, CIPDD, TetraQ-Pharmaceutics, Brisbane, Qld 4072, Australia.
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