| Synthesis of gamma-hydroxybutenolides applying crossed aldol condensation in the presence of a bulky lewis acid and their anti-tumor activity. | |
| | |
MedLine Citation:
|
PMID: 17827763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An improved synthesis of gamma-hydroxybutenolides 1a-d was achieved via crossed aldol condensation between aldehydes 2a-d and the protected gamma-hydroxy-beta-methylbutenolides 3 or 4 using the bulky Lewis acid, aluminum tris(2,6-diphenylphenoxide) (ATPH). Using this same methodology, the gamma-hydroxybutenolides 17a-d having various heteroaromatic rings were synthesized and their anti-tumor activities were evaluated. |
| | |
Authors:
|
Yumiko Yamano; Yumi Fujita; Yukari Mizuguchi; Kimie Nakagawa; Toshio Okano; Masayoshi Ito; Akimori Wada |
Related Documents
:
|
9447873 - Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on... 667493 - Presynaptic actions of gamma-aminobutyric acid and some antagonists in a slice preparat... 3315823 - Effectiveness of orthotopic liver transplantation on the restoration of cholesterol met... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Chemical & pharmaceutical bulletin Volume: 55 ISSN: 0009-2363 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-09-10 Completed Date: 2007-10-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
|
Languages: eng Pagination: 1365-70 Citation Subset: IM |
Affiliation:
|
Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University, Kobe, Japan. y-yamano@kobepharma-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldehydes
/
chemistry Antigens, CD11b / biosynthesis Antigens, CD14 / biosynthesis Antineoplastic Agents / chemical synthesis*, pharmacology Chromatography, High Pressure Liquid Flow Cytometry HL-60 Cells Humans Indicators and Reagents Magnetic Resonance Spectroscopy Sodium Oxybate / chemical synthesis*, pharmacology* Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Thymidine / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Aldehydes; 0/Antigens, CD11b; 0/Antigens, CD14; 0/Antineoplastic Agents; 0/Indicators and Reagents; 50-89-5/Thymidine; 502-85-2/Sodium Oxybate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis of (R)-curcumene and (R)-xanthorrizol based on 1,2-Aryl migration via phenonium ion.
Next Document: Withanolide A biogeneration in in vitro shoot cultures of ashwagandha (Withania somnifera DUNAL), a ...