| Synthesis of fluorinated indoles as RNA analogues. | |
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MedLine Citation:
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PMID: 18058498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleoside analogues are chemical means to investigate hydrogen bonds, base stacking, and solvation as the three predominant forces that are responsible for the stability of secondary structure of nucleic acids. To obtain deeper insight into the contributions of these interactions to RNA stability apart from the ones exerted by the predominant nucleosides we decided to synthesize some novel nucleic acid analogues where the nucleobases are replaced by fluoroindoles. Fluorinated indoles can be compared to fluorinated benzimidazoles to determine the role of nitrogen in five membered ring system. The synthesis of fluoroindole ribonucleosides is described here. |
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Authors:
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Jelena Bozilović; Joachim W Engels |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 26 ISSN: 1525-7770 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-03-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: United States |
Other Details:
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Languages: eng Pagination: 869-71 Citation Subset: IM |
Affiliation:
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Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzimidazoles
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chemical synthesis,
chemistry Halogenation Indoles / chemical synthesis*, chemistry Molecular Structure RNA / chemical synthesis*, chemistry RNA Stability Ribonucleosides / chemical synthesis*, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Benzimidazoles; 0/Indoles; 0/Ribonucleosides; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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