Document Detail

Synthesis of a fluorescent analogue of phosphatidylcholine.
MedLine Citation:
PMID:  4085088     Owner:  NLM     Status:  MEDLINE    
A fluorescent analogue of phosphatidylcholine was synthesized by acylation of 1-oleoyl-sn-glycero-3-phosphocholine with 6-N-(tert-butyloxycarbonyl)aminocaproic acid anhydride employing the catalyst 4-pyrrolidinopyridine. Removal of the protective group by treatment with HCl in chloroform was followed by subsequent reaction with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) to form the fluorescent analogue of phosphatidylcholine, 1-oleoyl-2-(NBD)aminocaproyl-sn-glycero-3-phosphocholine, in good yield and with high isomeric purity.
N Schmidt; G Gercken
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  38     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-02-26     Completed Date:  1986-02-26     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
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MeSH Terms
4-Chloro-7-nitrobenzofurazan / analogs & derivatives,  chemical synthesis*
Fluorescent Dyes
Indicators and Reagents
Magnetic Resonance Spectroscopy
Oxadiazoles / chemical synthesis*
Phosphatidylcholines / chemical synthesis*
Spectrometry, Fluorescence
Reg. No./Substance:
0/Fluorescent Dyes; 0/Indicators and Reagents; 0/Oxadiazoles; 0/Phosphatidylcholines; 10199-89-0/4-Chloro-7-nitrobenzofurazan; 99566-32-2/1-oleoyl-2-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproylphosphatidylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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