| Synthesis and evaluation of a novel lipid-peptide conjugate for functionalized liposome. | |
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MedLine Citation:
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PMID: 17317168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel lipid analog based on amino acids for liposome modification was developed. It consisted of three different kinds of amino acid derivatives and two fatty acids, and can react directly with the peptide synthesized first on resin by Fmoc solid-phase synthesis. In this study, lipid analog conjugated with HIV-TAT peptide (domain of human immunodeficiency virus TAT protein) was synthesized and successfully incorporated into liposome. The liposome containing the lipopeptide bearing HIV-TAT exhibited efficient cellular uptake. |
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Authors:
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Nobuhiro Yagi; Yuko Yano; Kentaro Hatanaka; Yuusaku Yokoyama; Hiroaki Okuno |
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Publication Detail:
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Type: Journal Article Date: 2007-02-04 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 17 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-06 Completed Date: 2007-07-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 2590-3 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals COS Cells Cercopithecus aethiops Chemistry, Pharmaceutical / methods* Chromatography, High Pressure Liquid Drug Design Fatty Acids / chemistry Gene Products, tat / chemistry* Lipids / chemistry* Liposomes / chemistry* Magnetic Resonance Spectroscopy Models, Chemical Molecular Conformation Peptides / chemistry* Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Gene Products, tat; 0/Lipids; 0/Liposomes; 0/Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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