Document Detail


Synthesis and evaluation of a novel lipid-peptide conjugate for functionalized liposome.
MedLine Citation:
PMID:  17317168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel lipid analog based on amino acids for liposome modification was developed. It consisted of three different kinds of amino acid derivatives and two fatty acids, and can react directly with the peptide synthesized first on resin by Fmoc solid-phase synthesis. In this study, lipid analog conjugated with HIV-TAT peptide (domain of human immunodeficiency virus TAT protein) was synthesized and successfully incorporated into liposome. The liposome containing the lipopeptide bearing HIV-TAT exhibited efficient cellular uptake.
Authors:
Nobuhiro Yagi; Yuko Yano; Kentaro Hatanaka; Yuusaku Yokoyama; Hiroaki Okuno
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Publication Detail:
Type:  Journal Article     Date:  2007-02-04
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  17     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  2590-3     Citation Subset:  IM    
Affiliation:
Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
COS Cells
Cercopithecus aethiops
Chemistry, Pharmaceutical / methods*
Chromatography, High Pressure Liquid
Drug Design
Fatty Acids / chemistry
Gene Products, tat / chemistry*
Lipids / chemistry*
Liposomes / chemistry*
Magnetic Resonance Spectroscopy
Models, Chemical
Molecular Conformation
Peptides / chemistry*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Gene Products, tat; 0/Lipids; 0/Liposomes; 0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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