| Synthesis and evaluation of novel caged DNA alkylating agents bearing 3,4-epoxypiperidine structure. | |
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MedLine Citation:
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PMID: 22614066 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Previously, we reported that the 3,4-epoxypiperidine structure, whose design was based on the active site of DNA alkylating antitumor antibiotics, azinomycins A and B, possesses prominent DNA cleavage activity. In this report, novel caged DNA alkylating agents, which were designed to be activated by UV irradiation, were synthesized by the introduction of four photo-labile protecting groups to a 3,4-epoxypiperidine derivative. The DNA cleavage activity and cytotoxicity of the caged DNA alkylating agents were examined under UV irradiation. Four caged DNA alkylating agents showed various degrees of bioactivity depending on the photosensitivity of the protecting groups. |
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Authors:
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Yuji Kawada; Tetsuya Kodama; Kazuyuki Miyashita; Takeshi Imanishi; Satoshi Obika |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-22 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: - ISSN: 1477-0539 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. obika@phs.osaka-u.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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