Document Detail

Synthesis and evaluation of in vitro antiviral activity of novel phenoxy acetic acid derivatives.
MedLine Citation:
PMID:  18951282     Owner:  NLM     Status:  MEDLINE    
Several substituted phenoxy acetic acid derived pyrazolines were synthesized by the reaction between 2-{4-[3-(2,4-dihydroxyphenyl)-3-oxo-1-propenyl]-2-methoxyphenoxy} acetic acid and substituted acid hydrazides and were tested for their in vitro cytotoxicity and antiviral activity. None of the compounds showed any specific antiviral activity [50% antivirally effective concentration (EC(50)) > or = 5-fold lower than minimum cytotoxic concentration]. The most cytotoxic of the series was 2-{4-[3-(2,4-dihydroxyphenyl)-1-(2-hydroxybenzoyl-4,5-dihydro-1H-5-pyrazolyl]-2-methoxyphenoxy}acetic acid (3(j)), with a minimum cytotoxic concentration of 0.16 microg/mL in human embryonic lung (HEL) cells.
M Shahar Yar; M Afroz Bakht; A A Siddiqui; M M Abdullah; Erik De Clercq
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of enzyme inhibition and medicinal chemistry     Volume:  24     ISSN:  1475-6374     ISO Abbreviation:  J Enzyme Inhib Med Chem     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2010-04-08     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150203     Medline TA:  J Enzyme Inhib Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  876-82     Citation Subset:  IM    
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, 110062, India.
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MeSH Terms
Acetic Acids / chemistry*,  pharmacology*,  toxicity
Antiviral Agents / chemical synthesis*,  chemistry,  pharmacology*,  toxicity
Cell Line
Lung / cytology,  embryology
Microbial Sensitivity Tests
Pyrazoles / chemistry*,  pharmacology*,  toxicity
Structure-Activity Relationship
Reg. No./Substance:
0/Acetic Acids; 0/Antiviral Agents; 0/Pyrazoles; 122-59-8/phenoxyacetic acid

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