Document Detail


Synthesis and evaluation of disubstituted N1- and N3-imidazolidin-2-ones acting as potential immunosuppressive agents.
MedLine Citation:
PMID:  15662949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
New N1-mono and N1, N2-disubstituted imidazolidin-2-one with a significant immunosuppressive activity have been discovered. Among the 17 synthesized and tested compounds, five of them showed maximal inhibition of proliferation of concanavallin A (Con A)- stimulated splenocytes at 90 microM, identical to that obtained with cyclosporin A (CsA) at 5 microM, an optimal concentration.
Authors:
Caroline Sabourin; Jean-Michel H Robert; Sylvie Robert-Piessard; Delphine Carbonnelle; Francois Lang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of enzyme inhibition and medicinal chemistry     Volume:  19     ISSN:  1475-6366     ISO Abbreviation:  J Enzyme Inhib Med Chem     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-24     Completed Date:  2006-02-28     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  101150203     Medline TA:  J Enzyme Inhib Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-65     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacochimie, UPRES EA 1155, Faculté de Pharmacie, F-44035 Nantes, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation / drug effects
Concanavalin A / antagonists & inhibitors,  pharmacology
Drug Evaluation, Preclinical
Female
Imidazolidines / chemical synthesis*,  chemistry,  pharmacology*
Immunosuppressive Agents / chemical synthesis*,  chemistry,  pharmacology*
Mice
Mice, Inbred C57BL
Molecular Structure
Spleen / cytology,  drug effects
Stereoisomerism
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Imidazolidines; 0/Immunosuppressive Agents; 11028-71-0/Concanavalin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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