| Synthesis and evaluation of dioleoyl glyceric acids showing antitrypsin activity. | |
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MedLine Citation:
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PMID: 21606621 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Previously, Lešová et al. reported the isolation and identification of metabolite OR-1, showing antitrypsin activity, produced during fermentation by Penicillium funiculosum. The structure of OR-1 was a mixture of glyceric acid (GA), esterified with C(14)-C(18) fatty acids, and oleic acid (C18:1) as the most predominant fatty acid (Folia Microbiol. 46, 21-23, 2001). In this study, dioleoyl D-GA and dioleoyl L-GA were synthesized via diesterification with oleoyl chloride, and their antitrypsin activities were evaluated using both a disk diffusion method and spectral absorption measurements. The results show that both compounds and their equivalent mixtures possess antitrypsin activities; however, their IC(50) values (approximately 2 mM) are much higher than that of OR-1 (4.25 µM), suggesting that dioleoyl GA does not play a major role in the OR-1 antitrypsin activity. |
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Authors:
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Hiroshi Habe; Tokuma Fukuoka; Shun Sato; Dai Kitamoto; Keiji Sakaki |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of oleo science Volume: 60 ISSN: 1347-3352 ISO Abbreviation: J Oleo Sci Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101175339 Medline TA: J Oleo Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 327-31 Citation Subset: IM |
Affiliation:
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Research Institute for Innovations in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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