| Synthesis and evaluation of aryl boronic acids as fluorescent artificial receptors for biological carbohydrates. | |
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MedLine Citation:
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PMID: 22177855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbohydrates in various forms play a vital role in numerous critical biological processes. The detection of such saccharides can give insight into the progression of such diseases such as cancer. Boronic acids react with 1,2 and 1,3 diols of saccharides in non-aqueous or basic aqueous media. Herein, we describe the design, synthesis and evaluation of three bisboronic acid fluorescent probes, each having about ten linear steps in its synthesis. Among these compounds that were evaluated, 9b was shown to selectively label HepG2, liver carcinoma cell line within a concentration range of 0.5-10 μM in comparison to COS-7, a normal fibroblast cell line. |
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Authors:
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Sandra Craig |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-11-25 |
Journal Detail:
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Title: Bioorganic chemistry Volume: 40 ISSN: 1090-2120 ISO Abbreviation: Bioorg. Chem. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-17 Completed Date: 2012-05-14 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 1303703 Medline TA: Bioorg Chem Country: United States |
Other Details:
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Languages: eng Pagination: 137-42 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4098, USA. scraig30@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Boronic Acids / chemical synthesis, chemistry* Carbohydrates / chemistry* Cell Line Cercopithecus aethiops Fluorescent Dyes / chemical synthesis*, chemistry Humans Kinetics Microscopy, Confocal Phenanthrenes / chemical synthesis*, chemistry |
| Grant Support | |
ID/Acronym/Agency:
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CA113917/CA/NCI NIH HHS; CA88343/CA/NCI NIH HHS; N01-CO-27184/CO/NCI NIH HHS; R21 CA088343-01/CA/NCI NIH HHS; R21 CA113917-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Boronic Acids; 0/Carbohydrates; 0/Fluorescent Dyes; 0/Phenanthrenes |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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