| Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate. | |
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MedLine Citation:
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PMID: 16084097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have synthesized a conjugate of cis-4,7,10,13,16,19-docosahexenoic acid (DHA) and 10-hydroxycamptothecin (HCPT), DHA-HCPT. The antitumor activity of DHA-HCPT was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia, Lewis lung carcinoma, and colon 38 adenocarcinoma. DHA-HCPT showed a greatly improved antitumor efficacy compared to HCPT. |
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Authors:
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Yuqiang Wang; Lianfa Li; Wei Jiang; James W Larrick |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 13 ISSN: 0968-0896 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-08-22 Completed Date: 2005-12-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 5592-9 Citation Subset: IM |
Affiliation:
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Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China. yuqiangwang2001@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy* Animals Antineoplastic Agents* / chemical synthesis, pharmacology Camptothecin / analogs & derivatives*, chemical synthesis, pharmacology Carcinoma, Lewis Lung / drug therapy* Cell Line, Tumor Cell Proliferation / drug effects Colonic Neoplasms / drug therapy* Disease Models, Animal Docosahexaenoic Acids* / chemical synthesis, pharmacology Drug Design Drug Screening Assays, Antitumor Humans Leukemia L1210 / drug therapy* Mice Molecular Conformation Stereoisomerism Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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CA 82949/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/DHA-HCPT conjugate; 25167-62-8/Docosahexaenoic Acids; 67656-30-8/10-hydroxycamptothecin; 7689-03-4/Camptothecin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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