Document Detail

Synthesis and evaluation of (99m)Tc-moxifloxacin, a potential infection specific imaging agent.
MedLine Citation:
PMID:  19900818     Owner:  NLM     Status:  MEDLINE    
To synthesize and evaluate a (99m)Tc labeled fluroquinolone, moxifloxacin as a potential bacteria specific infection imaging agent. A radiolabeling formulation including moxifloxacin, [Moxicip(TM) injection, Cipla] (4mg), sodium pertechnetate and stannous chloride (5microg) gave the best radiolabeling efficiency and moderately stable labeled (99m)Tc moxifloxacin. Quality control analysis was performed by ITLC. Rats and rabbit with infectious intramuscular lesions induced in either thigh with E. Colli were used for studying biodistribution and scintigraphic imaging of the labeled product. Imaging of an infected thigh of a rabbit was performed with a gamma-camera at various intervals. A good radiolabeling efficiency (90-95%) was obtained within 5min. No purification of the labeled product was done. Labeled product retained its radiochemical purity upto 85% even at 3h. Scintigraphy showed uptake in infectious lesions at 30min after injection, which remains constant upto 3h study. Abscess-to-muscle ratios were 1.60, 1.62, 1.74 and 1.75 at 30min, 1, 2 and 3h, respectively. Thus, (99m)Tc moxifloxacin, a new potential radiopharmaceutical has been developed for infection imaging agent.
Sankha Chattopadhyay; Sujata Saha Das; Susmita Chandra; Kakali De; Mridula Mishra; Bharat Ranjan Sarkar; Samarendu Sinha; Shantanu Ganguly
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2009-10-24
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  68     ISSN:  1872-9800     ISO Abbreviation:  Appl Radiat Isot     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  England    
Other Details:
Languages:  eng     Pagination:  314-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Radiopharmaceuticals Laboratory, Board of Radiation and Isotope Technology, Variable Energy Cyclotron Centre, 1/AF, Bidhan Nagar, Kolkata 700 064, India.
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MeSH Terms
Anti-Infective Agents / chemistry,  diagnostic use,  pharmacokinetics
Aza Compounds / chemistry,  diagnostic use*,  pharmacokinetics*
Escherichia coli Infections / metabolism*,  radionuclide imaging*
Feasibility Studies
Image Enhancement / methods
Isotope Labeling / methods
Metabolic Clearance Rate
Organ Specificity
Positron-Emission Tomography / methods*
Quinolines / chemistry,  diagnostic use*,  pharmacokinetics*
Radiopharmaceuticals / chemical synthesis,  diagnostic use,  pharmacokinetics
Rats, Wistar
Technetium / chemistry,  diagnostic use*,  pharmacokinetics*
Tissue Distribution
Reg. No./Substance:
0/Anti-Infective Agents; 0/Aza Compounds; 0/Quinolines; 0/Radiopharmaceuticals; 0/moxifloxacin; 7440-26-8/Technetium

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