| Synthesis of the epimer of pericosine B from (-)-quinic Acid. | |
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MedLine Citation:
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PMID: 15340204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Synthesis of the epimer of pericosine B from (-)-quinic acid was achieved. This synthesis involves some regioselective and stereoselective processes. The desired product showed lower cytotoxic activity in comparison with natural pericosine B against the P388 leukemia cell line. The result implies that the stereocenter of C-6 in natural pericosine B plays an important role in this activity. |
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Authors:
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Yoshihide Usami; Chikage Hatsuno; Hiroe Yamamoto; Manabu Tanabe; Atsushi Numata |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 52 ISSN: 0009-2363 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-01 Completed Date: 2005-02-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 1130-3 Citation Subset: IM |
Affiliation:
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Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1094, Japan. usami@gly.oups.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemical synthesis*, chemistry Cell Line, Tumor Mice Molecular Conformation Molecular Structure Quinic Acid / chemistry* Shikimic Acid / analogs & derivatives*, chemical synthesis*, chemistry, pharmacology Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/pericosine B; 138-59-0/Shikimic Acid; 77-95-2/Quinic Acid |
| Comments/Corrections | |
Erratum In:
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Chem Pharm Bull (Tokyo). 2005 Jun;53(6):721 Chem Pharm Bull (Tokyo). 2004 Dec;52(12):1511 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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