| Synthesis of enantiomerically enriched (R)-C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine. | |
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MedLine Citation:
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PMID: 22043239 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The method of Kouklovsky and coworkers for the enantioselective alkylation of cyclic N-naphthoyl derivatives of amino acids was used to introduce a (13)C label into one of the two enantiotopic methyl groups of 2-aminoisobutyric acid (Aib) by retentive alkylation of L-alanine with (13)CH(3)I. Conditions were identified for optimization of yield and enantiomeric purity, and the absolute configuration of the labelled product was established. |
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Authors:
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Stephen P Fletcher; Jordi Solà; Dean Holt; Robert A Brown; Jonathan Clayden |
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Publication Detail:
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Type: Journal Article Date: 2011-09-20 |
Journal Detail:
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Title: Beilstein journal of organic chemistry Volume: 7 ISSN: 1860-5397 ISO Abbreviation: Beilstein J Org Chem Publication Date: 2011 |
Date Detail:
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Created Date: 2011-11-01 Completed Date: 2011-11-10 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 101250746 Medline TA: Beilstein J Org Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 1304-9 Citation Subset: - |
Affiliation:
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School of Chemistry, University of Manchester, Oxford Rd., Manchester M13 9PL, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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