Document Detail


Synthesis of enantiomerically enriched (R)-C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine.
MedLine Citation:
PMID:  22043239     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The method of Kouklovsky and coworkers for the enantioselective alkylation of cyclic N-naphthoyl derivatives of amino acids was used to introduce a (13)C label into one of the two enantiotopic methyl groups of 2-aminoisobutyric acid (Aib) by retentive alkylation of L-alanine with (13)CH(3)I. Conditions were identified for optimization of yield and enantiomeric purity, and the absolute configuration of the labelled product was established.
Authors:
Stephen P Fletcher; Jordi Solà; Dean Holt; Robert A Brown; Jonathan Clayden
Related Documents :
17943179 - Metabolism and biological activities of topical 4-oxoretinoids in mouse skin.
3970539 - The growth-supporting activity of a retinoidal benzoic acid derivative and 4,4-difluoro...
3702709 - Quantification of physiological levels of retinoic acid.
20164929 - Rere controls retinoic acid signalling and somite bilateral symmetry.
568139 - In vitro metabolism and biological activity of all-trans-retinoic acid and its metaboli...
9321529 - All-trans-retinoic acid in acute promyelocytic leukemia.
5347519 - Single chain alkali resistance in hemoglobin rainier: beta 145 tyrosine-histidine.
18824209 - A matrix assisted laser desorption ionization time-of-flight mass spectrometry investig...
426179 - Antral patch esophagoplasty. a new procedure for acid-peptic esophageal stricture.
Publication Detail:
Type:  Journal Article     Date:  2011-09-20
Journal Detail:
Title:  Beilstein journal of organic chemistry     Volume:  7     ISSN:  1860-5397     ISO Abbreviation:  Beilstein J Org Chem     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-01     Completed Date:  2011-11-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101250746     Medline TA:  Beilstein J Org Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1304-9     Citation Subset:  -    
Affiliation:
School of Chemistry, University of Manchester, Oxford Rd., Manchester M13 9PL, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Parathyroid carcinoma: a review with three illustrative cases.
Next Document:  Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles.