| Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease. | |
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MedLine Citation:
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PMID: 20494577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds. |
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Authors:
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R Ramajayam; Kian-Pin Tan; Hun-Ge Liu; Po-Huang Liang |
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Publication Detail:
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Type: Journal Article Date: 2010-05-20 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 3569-72 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Computer Simulation Cysteine Endopeptidases Inhibitory Concentration 50 Models, Molecular Protease Inhibitors / chemical synthesis, pharmacology Protein Binding Pyrimidines / chemical synthesis*, pharmacology* SARS Virus / drug effects, enzymology Structure-Activity Relationship Viral Proteins / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Protease Inhibitors; 0/Pyrimidines; 0/Viral Proteins; EC 3.4.22.-/3C-like protease, SARS coronavirus; EC 3.4.22.-/Cysteine Endopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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