Document Detail


Synthesis and diversity analysis of lead discovery piperazine-2-carboxamide libraries.
MedLine Citation:
PMID:  10849899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A Lead Discovery Library of piperazine-2-carboxamide derivatives was produced for general screening. This paper discloses two novel solid phase synthetic routes used to produce 15,000 single compounds via the Irori directed sorting technique. Computational methods such as reagent clustering and library profiling were used to maximize reagent diversity and optimize pharmacokinetic parameters. The results of a four center pharmacophore analysis revealed the added diversity gained by using two independent synthetic routes.
Authors:
T F Herpin; G C Morton; A K Dunn; C Fillon; P R Menard; S Y Tang; J M Salvino; R F Labaudinière
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular diversity     Volume:  4     ISSN:  1381-1991     ISO Abbreviation:  Mol. Divers.     Publication Date:  1998  
Date Detail:
Created Date:  2000-09-28     Completed Date:  2000-09-28     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  9516534     Medline TA:  Mol Divers     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  221-32     Citation Subset:  IM    
Affiliation:
Rhone-Poulenc Rorer Research and Development, Collegeville, PA 19426, USA. timothy.herpin@bms.com
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MeSH Terms
Descriptor/Qualifier:
Combinatorial Chemistry Techniques*
Piperazines / chemical synthesis*
Chemical
Reg. No./Substance:
0/Piperazines

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