| Synthesis of disaccharide fragments of the AT-III binding domain of heparin and their sulfonatomethyl analogues. | |
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MedLine Citation:
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PMID: 21798526 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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d-Glucuronate and l-iduronate-containing disaccharides related to the antithrombin-binding domain of heparin were prepared. The carboxylic function of the uronic acid unit was formed on a disaccharide level in the case of the glucuronate, while on a monosaccharide level in the case of the iduronate derivatives. Synthesis of their sulfonic acid analogues was carried out analoguosly applying sulfonatomethyl-containing acceptors in the form of either salts or methyl esters. Significant difference could be observed in the methyl ether formation reactions of the sulfonatomethyl-containing uronate disaccharides and the non-sulfonic acid uronates. |
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Authors:
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Mihály Herczeg; László Lázár; Attila Mándi; Anikó Borbás; István Komáromi; András Lipták; Sándor Antus |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-24 |
Journal Detail:
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Title: Carbohydrate research Volume: - ISSN: 1873-426X ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-7-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0043535 Medline TA: Carbohydr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Research Group for Carbohydrates of The Hungarian Academy of Sciences, University of Debrecen, PO Box 94, H-4010 Debrecen, Hungary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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