Document Detail


Synthesis of dilinoleoyl-d-glyceric Acid and evaluation of its cytotoxicity to human dermal fibroblast and endothelial cells.
MedLine Citation:
PMID:  21852748     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A novel derivative of glyceric acid (GA), dilinoleoyl-D-glyceric acid (LA(2)-DGA), was synthesized from D-GA calcium salt and linoleoyl chloride and evaluated for cytotoxicity. The D-GA calcium salt was first reacted with 4-methoxybezylchloride, and the resulting compound was esterified with linoleoyl chloride. This reaction was followed by hydrolysis of the 4-methoxybenzyl moiety, yielding LA(2)-DGA. LA(2)-DGA was then subjected to cytotoxicity testing using normal human dermal fibroblasts and primary normal human dermal microvascular endothelial cells. LA(2)-DGA showed no significant toxic effects in either type of cell.
Authors:
Shun Sato; Hiroshi Habe; Tokuma Fukuoka; Dai Kitamoto; Keiji Sakaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oleo science     Volume:  60     ISSN:  1347-3352     ISO Abbreviation:  J Oleo Sci     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101175339     Medline TA:  J Oleo Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  483-7     Citation Subset:  IM    
Affiliation:
Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST).
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