Document Detail

Synthesis of the α,ω-dicarboxylic acid precursor of biotin by the canonical fatty acid biosynthetic pathway.
MedLine Citation:
PMID:  21435937     Owner:  NLM     Status:  MEDLINE    
Biotin synthesis requires the C7 α,ω-dicarboxylic acid, pimelic acid. Although pimelic acid was known to be primarily synthesized by a head to tail incorporation of acetate units, the synthetic mechanism was unknown. It has recently been demonstrated that in most bacteria the biotin pimelate moiety is synthesized by a modified fatty acid synthetic pathway in which the biotin synthetic intermediates are O-methyl esters disguised to resemble the canonical intermediates of the fatty acid synthetic pathway. Upon completion of the pimelate moiety, the methyl ester is cleaved. A very restricted set of bacteria have a different pathway in which the pimelate moiety is formed by cleavage of fatty acid synthetic intermediates by BioI, a member of the cytochrome P450 family.
John E Cronan; Steven Lin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-03-23
Journal Detail:
Title:  Current opinion in chemical biology     Volume:  15     ISSN:  1879-0402     ISO Abbreviation:  Curr Opin Chem Biol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-07     Completed Date:  2011-08-26     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9811312     Medline TA:  Curr Opin Chem Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  407-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Bacteria / metabolism*
Biosynthetic Pathways*
Biotin / biosynthesis
Fatty Acids / biosynthesis
Pimelic Acids / metabolism*
Grant Support
Reg. No./Substance:
0/Fatty Acids; 0/Pimelic Acids; 6SO6U10H04/Biotin

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