Document Detail


Synthesis of dextroamphetamine sulfate and methamphetamine hydrochloride from D-phenylalanine.
MedLine Citation:
PMID:  671259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Starting from D-phenylalanine, dextroamphetamine sulfate and methamphetamine hydrochloride were synthesized. The reaction sequence proceeds through three intermediates, in which the absolute configuration of the asymmetric carbon atom is changed but the relative configuration remains the same. Either product can be obtained from a common intermediate by altering the reductive conditions employed for the removal of a carbamate protecting group.
Authors:
D B Repke; D K Bates; W J Ferguson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  67     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-09-25     Completed Date:  1978-09-25     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1167-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Dextroamphetamine / chemical synthesis*
Methamphetamine / chemical synthesis*
Methods
Phenylalanine*
Chemical
Reg. No./Substance:
51-64-9/Dextroamphetamine; 537-46-2/Methamphetamine; 63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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