| Synthesis and development of poly(n-hydroxyethyl acrylamide)-ran-3-acrylamidophenylboronic Acid polymer fluid for potential application in affinity sensing of glucose. | |
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MedLine Citation:
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PMID: 22027298 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: In previous work, we described viscosity and permittivity microelectromechanical systems (MEMS) sensors for continuous glucose monitoring (CGM) using poly[acrylamide-ran-3-acrylamidophenylboronic acid (PAA-ran-PAAPBA). In order to enhance our MEMS device antifouling properties, a novel, more hydrophilic polymer-sensing fluid was developed. Method: To optimize sensing performance, we synthesized biocompatible copolymers poly(N-hydroxyethyl acrylamide)-ran-3-acrylamidophenylboronic acid (PHEAA-ran-PAAPBA) and developed its sensing fluid for viscosity-based glucose sensing. Key factors such as polymer composition and molecular weight were investigated in order to optimize viscometric responses. Results: Compared with PAA-ran-PAAPBA fluid of a similar binding moiety percentage, PHEAA-ran-PAAPBA showed comparable high binding specificity to glucose in a reversible manner and even better performance in glucose sensing in terms of glucose sensing range (27-468 mg/ml) and sensitivity (within 3% standard error of estimate). Preliminary experiment on a MEMS viscometer demonstrated that the polymer fluid was able to sense the glucose concentration. Conclusions: Our MEMS systems using PHEAA-ran-PAAPBA will possess enhanced implantable traits necessary to enable CGM in subcutaneous tissues. |
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Authors:
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Siqi Li; Erin N Davis; Xian Huang; Bing Song; Rebecca Peltzman; David M Sims; Qiao Lin; Qian Wang |
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Publication Detail:
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Type: Journal Article Date: 2011-09-01 |
Journal Detail:
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Title: Journal of diabetes science and technology Volume: 5 ISSN: 1932-2968 ISO Abbreviation: J Diabetes Sci Technol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101306166 Medline TA: J Diabetes Sci Technol Country: United States |
Other Details:
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Languages: eng Pagination: 1060-7 Citation Subset: IM |
Copyright Information:
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© 2011 Diabetes Technology Society. |
Affiliation:
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Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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