Document Detail

Synthesis of deuterium-labelled fluorobenzoic acids to be used as internal standards in isotope dilution mass spectrometry.
MedLine Citation:
PMID:  24499142     Owner:  NLM     Status:  Publisher    
A method for the deuterium labelling of fluorobenzoic acids (FBAs) via acidic H/D exchange of the aromatic hydrogen atoms in concentrated D2SO4 is described. The synthesis is shown to be easy, fast, low-priced and without the use of catalysts or further purification. The use of at least double-deuterated FBAs as internal standards in organic isotope dilution mass spectrometry allows the determination of FBAs in complex matrices with highest possible accuracy in combination with a simplified analytical evaluation.
Karsten Müller; Andreas Seubert
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-5
Journal Detail:
Title:  Isotopes in environmental and health studies     Volume:  -     ISSN:  1477-2639     ISO Abbreviation:  Isotopes Environ Health Stud     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602611     Medline TA:  Isotopes Environ Health Stud     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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