Document Detail


Synthesis and derivatisation of a novel spiro[1-benzofuran-2,4'-piperidin]-3-one scaffold.
MedLine Citation:
PMID:  16106306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis of a novel spiro[1-benzofuran-2,4'-piperidin]-3-one scaffold has been achieved in five steps with an overall yield of 47%. The versatility of the spiropiperidine scaffold in the context of library synthesis is exemplified by selective and sequential derivatisation of the amino and aryl bromide functional groups, including the development of multi-step telescope reaction matrices.
Authors:
Rowan A Wilson; Lai Chan; Robin Wood; Richard C D Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-03
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  3     ISSN:  1477-0520     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-17     Completed Date:  2006-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  3228-35     Citation Subset:  IM    
Affiliation:
School of Chemistry, University of Southampton, Southampton, Hants SO17 1BJ, UK.
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MeSH Terms
Descriptor/Qualifier:
Benzofurans / chemical synthesis*,  chemistry
Cyclopentanes / chemistry,  isolation & purification*,  pharmacology*
Ketones / chemistry,  isolation & purification*,  pharmacology*
Molecular Structure
Phloroglucinol / analogs & derivatives*,  chemistry,  isolation & purification,  pharmacology
Piperidines / chemical synthesis*,  chemistry
Spiro Compounds / chemical synthesis*,  chemistry
Stereoisomerism
Chemical
Reg. No./Substance:
0/Benzofurans; 0/Cyclopentanes; 0/Ketones; 0/Piperidines; 0/Spiro Compounds; 0/bullataketal A; 0/bullatenone; 0/spiro(1-benzofuran-2,4'-piperidin)-3-one; 108-73-6/Phloroglucinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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