| Synthesis and derivatisation of a novel spiro[1-benzofuran-2,4'-piperidin]-3-one scaffold. | |
| | |
MedLine Citation:
|
PMID: 16106306 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The synthesis of a novel spiro[1-benzofuran-2,4'-piperidin]-3-one scaffold has been achieved in five steps with an overall yield of 47%. The versatility of the spiropiperidine scaffold in the context of library synthesis is exemplified by selective and sequential derivatisation of the amino and aryl bromide functional groups, including the development of multi-step telescope reaction matrices. |
| | |
Authors:
|
Rowan A Wilson; Lai Chan; Robin Wood; Richard C D Brown |
Related Documents
:
|
537916 - The use of barium salts of protected deoxyribonucleoside-3' p-chlorophenyl phosphates f... 16774256 - Selective synthesis of epolactaene featuring efficient construction of methyl (z)-2-iod... 11483046 - First total synthesis of (+/-)-stemonamide and (+/-)-isostemonamide. 19603746 - Pyridinium ylide-assisted one-pot two-step tandem synthesis of polysubstituted cyclopro... 22511576 - Surface modification of nanodiamond under bingel-hirsch conditions. 17718406 - Alcohol metabolism's damaging effects on the cell: a focus on reactive oxygen generatio... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-08-03 |
Journal Detail:
|
Title: Organic & biomolecular chemistry Volume: 3 ISSN: 1477-0520 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2005 Sep |
Date Detail:
|
Created Date: 2005-08-17 Completed Date: 2006-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
|
Languages: eng Pagination: 3228-35 Citation Subset: IM |
Affiliation:
|
School of Chemistry, University of Southampton, Southampton, Hants SO17 1BJ, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Benzofurans
/
chemical synthesis*,
chemistry Cyclopentanes / chemistry, isolation & purification*, pharmacology* Ketones / chemistry, isolation & purification*, pharmacology* Molecular Structure Phloroglucinol / analogs & derivatives*, chemistry, isolation & purification, pharmacology Piperidines / chemical synthesis*, chemistry Spiro Compounds / chemical synthesis*, chemistry Stereoisomerism |
| Chemical | |
Reg. No./Substance:
|
0/Benzofurans; 0/Cyclopentanes; 0/Ketones; 0/Piperidines; 0/Spiro Compounds; 0/bullataketal A; 0/bullatenone; 0/spiro(1-benzofuran-2,4'-piperidin)-3-one; 108-73-6/Phloroglucinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nitric oxide release from the unimolecular decomposition of the superoxide radical anion adduct of c...
Next Document: A cytotoxic triketone-phloroglucinol-bullatenone hybrid from Lophomyrtus bullata.