Document Detail


Synthesis of dehydroabietic acid-modified chitosan and its drug release behavior.
MedLine Citation:
PMID:  18976985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new type of chitosan derivative, dehydroabietic acid-modified chitosan (DAMC), was synthesized by the acylation reaction of chitosan with dehydroabietic acid chloride (DHAC) under microwave irradiation. The resulting product (DAMC) was characterized by FT-IR, UV, (1)H NMR, X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), and elemental analysis. The degree of substitution (DS) of DAMC was 16.5%. And chitosan and DAMC were used as carriers of fenoprofen calcium (FC), and their controlled release behavior in artificial intestinal juice was studied. The results showed that the controlled release of FC from the carrier of DAMC is better than that from original chitosan.
Authors:
Wengui Duan; Changmao Shen; Huaxiang Fang; Guang Hua Li
Related Documents :
6704995 - The synthesis of some fluoro derivatives of sucrose.
20112295 - An improved procedure for the synthesis of dehydroamino acids and dehydropeptides from ...
18044925 - Nitration versus nitrosation chemistry of menthofuran: remarkable fragmentation and dim...
14570455 - Facile synthesis of a fullerene-barbituric acid derivative and supramolecular catalysis...
7295805 - Isolation and structural studies of the neutral oligosaccharide units from bovine glyco...
13999335 - The influence of diet on the quality of faecal fat in patients with and without steator...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-14
Journal Detail:
Title:  Carbohydrate research     Volume:  344     ISSN:  1873-426X     ISO Abbreviation:  Carbohydr. Res.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043535     Medline TA:  Carbohydr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM    
Affiliation:
School of Chemistry and Chemical Engineering, Guangxi University, No. 100, Daxue Road, Nanning, Guangxi 530004, People's Republic of China. wgduan@gxu.edu.cn
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chitosan / chemical synthesis*,  chemistry*
Diterpenes, Abietane / chemistry*
Drug Delivery Systems
Fenoprofen / chemistry
Magnetic Resonance Spectroscopy
Microscopy, Electron, Scanning
Molecular Structure
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction
Chemical
Reg. No./Substance:
0/Diterpenes, Abietane; 1740-19-8/dehydroabietic acid; 31879-05-7/Fenoprofen; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synthesis of a heptasaccharide fragment of the mannan from Candida guilliermondii cell wall and its ...
Next Document:  Mental movements without magnitude? A study of spatial biases in symbolic arithmetic.