Document Detail

Synthesis of dehydroabietic acid-modified chitosan and its drug release behavior.
MedLine Citation:
PMID:  18976985     Owner:  NLM     Status:  MEDLINE    
A new type of chitosan derivative, dehydroabietic acid-modified chitosan (DAMC), was synthesized by the acylation reaction of chitosan with dehydroabietic acid chloride (DHAC) under microwave irradiation. The resulting product (DAMC) was characterized by FT-IR, UV, (1)H NMR, X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), and elemental analysis. The degree of substitution (DS) of DAMC was 16.5%. And chitosan and DAMC were used as carriers of fenoprofen calcium (FC), and their controlled release behavior in artificial intestinal juice was studied. The results showed that the controlled release of FC from the carrier of DAMC is better than that from original chitosan.
Wengui Duan; Changmao Shen; Huaxiang Fang; Guang Hua Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-14
Journal Detail:
Title:  Carbohydrate research     Volume:  344     ISSN:  1873-426X     ISO Abbreviation:  Carbohydr. Res.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043535     Medline TA:  Carbohydr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM    
School of Chemistry and Chemical Engineering, Guangxi University, No. 100, Daxue Road, Nanning, Guangxi 530004, People's Republic of China.
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MeSH Terms
Chitosan / chemical synthesis*,  chemistry*
Diterpenes, Abietane / chemistry*
Drug Delivery Systems
Fenoprofen / chemistry
Magnetic Resonance Spectroscopy
Microscopy, Electron, Scanning
Molecular Structure
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction
Reg. No./Substance:
0/Diterpenes, Abietane; 1740-19-8/dehydroabietic acid; 31879-05-7/Fenoprofen; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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