| Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives. | |
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MedLine Citation:
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PMID: 17945208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dioscin derivatives (1-12) with a variety of substitutions at the 6'-OH of the chacotriosyl residue and the 3',6'-anhydrosaponin derivatives (26, 30, and 32) were synthesized. All these derivatives showed much lower cytotoxicity than that of the parent dioscin, while their hemolytic activities were partially retained depending on the various 6'-O-substitutions. |
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Authors:
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Wei Li; Zaozao Qiu; Yibing Wang; Yichun Zhang; Ming Li; Jia Yu; Lihong Zhang; Ziyan Zhu; Biao Yu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-19 |
Journal Detail:
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Title: Carbohydrate research Volume: 342 ISSN: 0008-6215 ISO Abbreviation: Carbohydr. Res. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-23 Completed Date: 2008-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0043535 Medline TA: Carbohydr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2705-15 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Death
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drug effects Cell Line, Tumor Diosgenin / analogs & derivatives*, chemical synthesis, chemistry, pharmacology, toxicity Erythrocytes / cytology, drug effects Hemolysis / drug effects* Humans Saponins / chemical synthesis, chemistry, pharmacology, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Saponins; 19057-60-4/dioscin; 512-04-9/Diosgenin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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