Document Detail


Synthesis and cytotoxicity evaluation of novel pyrido[3,4-d]pyrimidine derivatives as potential anticancer agents.
MedLine Citation:
PMID:  25429348     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A new series of 4-substituted 2-amino pyrido[3,4-d]pyrimidine derivatives has been designed and synthesized as potential anticancer agents. These compounds were prepared from a common intermediate, 4-chloro-8-methoxy pyrido[3,4-d]pyrimidin-2-amine, followed by palladium catalyzed cross-coupling reactions or nucleophilic aromatic substitutions at the C-4 position. Evaluation of the representative analogs using the US National Cancer Institute's 60 human cancer cell line (NCI 60) panel identified some of these compounds as exhibiting highly selective activities against breast cancer and renal cancer cell lines. A structure-activity relationship (SAR) study was explored to facilitate further development of this new class of compounds.
Authors:
Linyi Wei; Sanjay V Malhotra
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  MedChemComm     Volume:  3     ISSN:  2040-2503     ISO Abbreviation:  Medchemcomm     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  2014-11-28    
Medline Journal Info:
Nlm Unique ID:  101531525     Medline TA:  Medchemcomm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1250-1257     Citation Subset:  -    
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