Document Detail


Synthesis and cytotoxicity evaluation of novel acylated starch nanoparticles.
MedLine Citation:
PMID:  23247257     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Starch nanoparticles (StNPs) were acylated under ambient conditions to obtain various nanosized derivatives formed stable suspension in water and soluble in organic solvents. The degree of substitution (DS) was determined using (1)H NMR technique. The cytotoxicity potential of the derivatised StNPs was evaluated in mouse embryonic fibroblast (3T3L1) cells and A549 tumor cell line using MTT cell viability assay. Other parameters that determine the oxidative stress viz., reactive oxygen species (ROS) generation, intracellular reduced glutathione (GSH), superoxide generation and acridine orange/ethidium bromide staining were also investigated. The present study led to the conclusion that cytotoxic activity of acylated starch nanoparticles was dependent on their dosage, DS and type of substitution. The non-toxic nature in non-cancerous cells reveals that the nanoparticles (NPs) can be used for cancer therapy and drug delivery. The nanoparticles also offered reasonable binding propensity with CT-DNA.
Authors:
Sonal Thakore; Mayur Valodkar; Jigar Y Soni; Komal Vyas; Rajendrasinh N Jadeja; Ranjitsinh V Devkar; Puran Singh Rathore
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-13
Journal Detail:
Title:  Bioorganic chemistry     Volume:  46C     ISSN:  1090-2120     ISO Abbreviation:  Bioorg. Chem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-12-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1303703     Medline TA:  Bioorg Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  26-30     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, Gujarat, India. Electronic address: chemistry2797@yahoo.com.
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