| Synthesis and cytotoxic effect of carbocyclic potential minor groove binders. | |
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MedLine Citation:
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PMID: 14987984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New carbocyclic potential minor groove binders were synthesised, using 3-nitrobenzoyl chloride and aliphatic alpha,omega-diamines with three, four and five methylene fragments. The half structures, compounds IV-VI can be compared to bis-amidines, compounds X-XII to bis-netropsin. All of the compounds were investigated antiproliferative and cytotoxic effects in the standard cell line of mammalian tumour MCF-7. |
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Authors:
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Danuta Bartulewicz; Tomasz Anchim; Milena Dabrowska; Krystyna Midura-Nowaczek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Farmaco (Società chimica italiana : 1989) Volume: 59 ISSN: 0014-827X ISO Abbreviation: Farmaco Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-27 Completed Date: 2004-06-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8912641 Medline TA: Farmaco Country: Italy |
Other Details:
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Languages: eng Pagination: 211-4 Citation Subset: IM |
Affiliation:
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Department of Organic Chemistry, Medical University of Białystok, Mickiewicza 2a, Białystok 15222, Poland. dbartule@amb.edu.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acids, Carbocyclic
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chemical synthesis*,
pharmacology* Antineoplastic Agents / chemical synthesis*, pharmacology* Apoptosis / drug effects Cell Line, Tumor Cell Survival / drug effects Chemistry, Physical Chromatography, Thin Layer DNA / chemistry, drug effects* Drug Design Drug Screening Assays, Antitumor Humans Indicators and Reagents Magnetic Resonance Spectroscopy Physicochemical Phenomena Spectrophotometry, Ultraviolet Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Acids, Carbocyclic; 0/Antineoplastic Agents; 0/Indicators and Reagents; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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