| Synthesis and cytotoxic activity of substituted luotonin A derivatives. | |
| | |
MedLine Citation:
|
PMID: 15501036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Luotonin A is a cytotoxic alkaloid that has been shown to inhibit topoisomerase I via stabilization of the binary complex topoisomerase-DNA in the same fashion as camptothecin. The synthesis and the cytotoxic activity on the lung carcinoma cell line H460 of a series of derivatives of Luotonin A is reported. The compounds inhibit topoisomerase I but show weak cytotoxic activity, thus confirming the peculiarity of ring E of camptothecin for antitumor activity. |
| | |
Authors:
|
Sabrina Dallavalle; Lucio Merlini; Giovanni Luca Beretta; Stella Tinelli; Franco Zunino |
Related Documents
:
|
20074836 - Novel antileishmanial chalconoids: synthesis and biological activity of 1- or 3-(6-chlo... 11197346 - Participation of the beta-hydroxyketone part for potent cytotoxicity of callystatin a, ... 15633996 - Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins. 12088436 - Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new relate... 20074836 - Novel antileishmanial chalconoids: synthesis and biological activity of 1- or 3-(6-chlo... 7763626 - Three flavone glycosides from gelonium multiflorum. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: 14 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2004 Dec |
Date Detail:
|
Created Date: 2004-10-25 Completed Date: 2005-03-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
|
Languages: eng Pagination: 5757-61 Citation Subset: IM |
Affiliation:
|
Dipartimento di Scienze Molecolari Agroalimentari, Sezione di Chimica, Università di Milano, Via Celoria 2, 20133 Milano, Italy. sabrina.dallavalle@unimi.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Line, Tumor DNA Topoisomerases, Type I / antagonists & inhibitors, metabolism Dose-Response Relationship, Drug Enzyme Inhibitors / chemical synthesis, toxicity Humans Pyrroles / chemical synthesis*, toxicity* Quinones / chemical synthesis*, toxicity* |
| Chemical | |
Reg. No./Substance:
|
0/Enzyme Inhibitors; 0/Pyrroles; 0/Quinones; 0/luotonin A; EC 5.99.1.2/DNA Topoisomerases, Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alpha-beta chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence ...
Next Document: Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamo...