| Synthesis and cytotoxic activity of some novel polycyclic gamma-butyrolactones. | |
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MedLine Citation:
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PMID: 18707881 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Baeyer-Villiger oxidation of 5-aryl-7,11,11-trimethyltricyclo[5.4.0.0(3,6)]-undec-1-en-4-ones 4a-h by H(2)O(2) and formic acid in methanol yields mixtures of 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-1-ones 8a-h and 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-2-ones 9a-h in high yields. The obtained butyrolactones 8a-h display cytotoxic activity against a number of human cancer cells. |
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Authors:
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M P S Ishar; Tilak Raj; Satyam Kumar Agrawal; A K Saxena; Lakhwinder Singh; Rajinder Singh; Surinderjit Singh Bhella |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-27 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 18 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-29 Completed Date: 2008-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 4809-12 Citation Subset: IM |
Affiliation:
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Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143 005, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Butyrolactone
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analogs & derivatives,
chemical synthesis*,
toxicity* Antineoplastic Agents / chemical synthesis, toxicity Cell Line, Tumor Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Female Growth Inhibitors / chemical synthesis*, toxicity Humans Male Polycyclic Compounds / chemical synthesis*, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Growth Inhibitors; 0/Polycyclic Compounds; 96-48-0/4-Butyrolactone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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