Document Detail

Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity.
MedLine Citation:
PMID:  15558956     Owner:  NLM     Status:  MEDLINE    
The synthesis and selective biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and some of their derivatives were carried out. Compound 13 was found to be most potent cytotoxic agent with LD50 = 126.69 microg/ml. In antibacterial assay the compounds showed a broad spectrum of activities. Compound 11 exhibited a very high degree of plant growth inhibition at three levels of concentration. Compound 4 showed very promising antifungal activity against Candida albicans. Compounds 12 and 13 demonstrated excellent antioxidant activity.
Khalid Mohammed Khan; Zafar S Saify; Muhammad Zarrar Khan; Zia-Ullah; Iqbal M Choudhary; Atta-Ur-Rahman; Shahnaz Perveen; Zahid H Chohan; Claudiu T Supuran
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of enzyme inhibition and medicinal chemistry     Volume:  19     ISSN:  1475-6366     ISO Abbreviation:  J Enzyme Inhib Med Chem     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-11-22     Completed Date:  2005-02-08     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  101150203     Medline TA:  J Enzyme Inhib Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  373-9     Citation Subset:  IM    
HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
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MeSH Terms
Anti-Infective Agents / chemical synthesis*,  chemistry,  pharmacology*
Antioxidants / chemical synthesis*,  chemistry,  pharmacology*
Araceae / drug effects
Artemia / drug effects
Bacteria / drug effects
Biological Assay / methods
Cell Survival / drug effects
Coumarins / chemical synthesis*,  chemistry,  pharmacology*
Fungi / drug effects
Microbial Sensitivity Tests
Molecular Structure
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antioxidants; 0/Coumarins

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