Document Detail


Synthesis and conformational studies in solution of sequential copolypeptides: poly(L-prolyl-L-alpha-phenylglycyl-L-proline).
MedLine Citation:
PMID:  1115764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High molecular weight poly(L-porlyl-L-alpha-phenylglycyl-L-proline) was synthesized by condensation of L-prolyl-L-alpha-phenylglycyl-L-proline pentachlorophenyl ester in N,N-dimethylformamide. The solution properties of this material have been investigated by circular dichroism and 220-MHz nuclear magnetic resonance spectroscopy in solvents such as trifluoroethanol (F3EtOH), chloroform, trifluoroacetic acid (F3CCOOH), chloroform-F3CCOOH and F3EtOH-F3CCOOH mixtures. Ordered structures can be formed in F3EtOH and chloroform, which we believe to be similar to the poly-L-proline II form. The ordered form easily undergoes a conformational transition to an unordered form upon addition of small amounts of F3CCOOH to the chloroform solution. The ordered structure is not disrupted upon addition of 12 per cent F3CCOOH to a F3EtOH solution of the polypeptide.
Authors:
M Palumbo; R L Rodin; M Goodman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Biochemistry     Volume:  14     ISSN:  0006-2960     ISO Abbreviation:  Biochemistry     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-06-02     Completed Date:  1975-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370623     Medline TA:  Biochemistry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  485-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chloroform
Circular Dichroism
Ethanol / analogs & derivatives
Fluoroacetates
Glycine* / analogs & derivatives
Magnetic Resonance Spectroscopy
Peptides / chemical synthesis*
Proline*
Protein Conformation
Chemical
Reg. No./Substance:
0/Fluoroacetates; 0/Peptides; 147-85-3/Proline; 56-40-6/Glycine; 64-17-5/Ethanol; 67-66-3/Chloroform

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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