| Synthesis and colon-specific drug delivery of a poly(acrylic acid-co-acrylamide)/MBA nanosized hydrogel. | |
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MedLine Citation:
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PMID: 18973725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous administration of 5-fluorouracil (5-FU) for colon cancer therapy produces severe systemic side-effects due to its cytotoxic effect on normal cells. The main objective of the present study was to develop novel oral site-specific delivery of 5-FU to the colon with less drug being released in the stomach or small intestine using biodegradable hydrogel, hydrogel nanoparticles and comparing the targeting efficiency of 5-FU to colon from both. Poly(acrylic acid-co-acrylamide) (P(AA-co-Am)) normal hydrogel and hydrogel nanoparticles (HN) were synthesized by free radical polymerization using N,N-methylene-bis-acrylamide (MBA) as cross-linker, potassium persulfate as reaction initiator and 5-FU was loaded. HN were found to be degradable in physiological medium and showed comparatively higher swelling in rat caecal medium (RCM). 5-FU entrapment was increased by increasing Am (wt%) monomer feed. In vitro release of 5-FU from normal hydrogel and HN in pH progressive medium, it was found that a AA/Am ratio of 25:75 showed higher release in RCM. The Higuchi model yielded good adjustment of in vitro release kinetics. A higher amount of 5-FU reached the colon in HN (61 +/- 2.1%) than normal hydrogel (40 +/- 3.6%) by organ biodistribution studies in albino rats. |
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Authors:
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Debajyoti Ray; Dillip K Mohapatra; Ranjit K Mohapatra; Guru P Mohanta; Prafulla K Sahoo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomaterials science. Polymer edition Volume: 19 ISSN: 0920-5063 ISO Abbreviation: J Biomater Sci Polym Ed Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-31 Completed Date: 2009-03-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007393 Medline TA: J Biomater Sci Polym Ed Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1487-502 Citation Subset: IM |
Affiliation:
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P.G. Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Naharakanta, Bhubaneswar, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylamides
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chemistry* Animals Biocompatible Materials / chemistry Colon / metabolism* Cross-Linking Reagents / chemistry Drug Carriers / chemical synthesis*, chemistry, pharmacokinetics Fluorouracil / administration & dosage, metabolism Hydrogels / chemical synthesis*, chemistry, pharmacokinetics Intestine, Small / metabolism Kinetics Male Microscopy, Electron, Transmission Nanoparticles / chemistry* Organ Specificity Particle Size Rats Spectroscopy, Fourier Transform Infrared Stomach / metabolism Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Acrylamides; 0/Biocompatible Materials; 0/Cross-Linking Reagents; 0/Drug Carriers; 0/Hydrogels; 0/poly(acrylamide-co-acrylic acid); 110-26-9/N,N'-methylenebisacrylamide; 51-21-8/Fluorouracil |
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