Document Detail


Synthesis and colon-specific drug delivery of a poly(acrylic acid-co-acrylamide)/MBA nanosized hydrogel.
MedLine Citation:
PMID:  18973725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intravenous administration of 5-fluorouracil (5-FU) for colon cancer therapy produces severe systemic side-effects due to its cytotoxic effect on normal cells. The main objective of the present study was to develop novel oral site-specific delivery of 5-FU to the colon with less drug being released in the stomach or small intestine using biodegradable hydrogel, hydrogel nanoparticles and comparing the targeting efficiency of 5-FU to colon from both. Poly(acrylic acid-co-acrylamide) (P(AA-co-Am)) normal hydrogel and hydrogel nanoparticles (HN) were synthesized by free radical polymerization using N,N-methylene-bis-acrylamide (MBA) as cross-linker, potassium persulfate as reaction initiator and 5-FU was loaded. HN were found to be degradable in physiological medium and showed comparatively higher swelling in rat caecal medium (RCM). 5-FU entrapment was increased by increasing Am (wt%) monomer feed. In vitro release of 5-FU from normal hydrogel and HN in pH progressive medium, it was found that a AA/Am ratio of 25:75 showed higher release in RCM. The Higuchi model yielded good adjustment of in vitro release kinetics. A higher amount of 5-FU reached the colon in HN (61 +/- 2.1%) than normal hydrogel (40 +/- 3.6%) by organ biodistribution studies in albino rats.
Authors:
Debajyoti Ray; Dillip K Mohapatra; Ranjit K Mohapatra; Guru P Mohanta; Prafulla K Sahoo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomaterials science. Polymer edition     Volume:  19     ISSN:  0920-5063     ISO Abbreviation:  J Biomater Sci Polym Ed     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-31     Completed Date:  2009-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007393     Medline TA:  J Biomater Sci Polym Ed     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1487-502     Citation Subset:  IM    
Affiliation:
P.G. Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Naharakanta, Bhubaneswar, India.
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MeSH Terms
Descriptor/Qualifier:
Acrylamides / chemistry*
Animals
Biocompatible Materials / chemistry
Colon / metabolism*
Cross-Linking Reagents / chemistry
Drug Carriers / chemical synthesis*,  chemistry,  pharmacokinetics
Fluorouracil / administration & dosage,  metabolism
Hydrogels / chemical synthesis*,  chemistry,  pharmacokinetics
Intestine, Small / metabolism
Kinetics
Male
Microscopy, Electron, Transmission
Nanoparticles / chemistry*
Organ Specificity
Particle Size
Rats
Spectroscopy, Fourier Transform Infrared
Stomach / metabolism
Tissue Distribution
Chemical
Reg. No./Substance:
0/Acrylamides; 0/Biocompatible Materials; 0/Cross-Linking Reagents; 0/Drug Carriers; 0/Hydrogels; 0/poly(acrylamide-co-acrylic acid); 110-26-9/N,N'-methylenebisacrylamide; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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