Document Detail


Synthesis of chiral 13C,77Se-labeled selones.
MedLine Citation:
PMID:  15255756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stable isotope-labeled N-acyl selones have been constructed in fewer than four steps from readily available starting materials. Site-specific labeling was achieved using the following synthons: bromo[2-(13)C]acetic acid, [(13)C]formic acid, and elemental (77)Se. These labeled selones have been found to provide unique insights into enolate structure and may be useful in the detection and quantitation of remotely disposed chiral centers in compounds in short supply.
Authors:
Morgane Ollivault-Shiflett; David B Kimball; L A Pete Silks
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  69     ISSN:  0022-3263     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-16     Completed Date:  2004-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5150-2     Citation Subset:  IM    
Affiliation:
Los Alamos National Laboratory, Bioscience Division, the Biotechnology, Spectroscopy, and Isotope Chemistry group (B-SIC), NIH National Stable Isotope Resource, MS E529, Los Alamos, NM 87545, USA. pete-silks@lanl.gov
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MeSH Terms
Descriptor/Qualifier:
Carbon Isotopes
Isotopes
Magnetic Resonance Spectroscopy
Molecular Structure
Selenium Compounds / chemistry*
Grant Support
ID/Acronym/Agency:
RR 02231/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Isotopes; 0/Selenium Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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