| Synthesis and characterization of thiomers of polyaspartamide type. | |
| | |
MedLine Citation:
|
PMID: 15707748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Synthesis of poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-thioglycolic acid (PHEA-TGA) conjugate as a new polyaspartamide thiomer is described. The parent polymer PHEA is chemically modified by introducing sulphydryl-bearing compound thioglycolic acid. By varying the reaction conditions several batches of PHEA-TGA conjugates were prepared and analyzed. Tensile studies revealed that total work of adhesion of PHEA-TGA increased more than twice compared to the unmodified polymer. Microparticles prepared from the thiolated polymer preserved its bioadhesive properties. |
| | |
Authors:
|
M Bubenik Bilicić; J Filipović-Grcić; A Martinac; M Barbarić; B Zorc; B Cetina-Cizmek; P Tudja |
Related Documents
:
|
3349208 - Collisional spectroscopy as a screening procedure for the determination of 2-(2-furoyl)... 22079738 - Optimization by factorial analysis of caprylic acid precipitation of non-immunoglobulin... 1101958 - Polynucleotide analogs: acrylic acid and maleic acid copolymers of 1-vinyluracil and 9-... 18492158 - Development of hydrogel patch for controlled release of alpha-hydroxy acid contained in... 4159288 - Degradation of ribonucleic acid in mouse fibroblasts treated with actinomycin. 11429178 - Effect of xanthurenic acid on infectivity of plasmodium falciparum to anopheles stephensi. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-12-29 |
Journal Detail:
|
Title: International journal of pharmaceutics Volume: 291 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2005 Mar |
Date Detail:
|
Created Date: 2005-02-14 Completed Date: 2006-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 211-9 Citation Subset: IM |
Affiliation:
|
PLIVA-Research Institute, Ltd., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chemistry, Pharmaceutical
/
methods Particle Size Peptides / analysis, chemical synthesis* Polymers / analysis, chemical synthesis* Spectroscopy, Near-Infrared / methods Technology, Pharmaceutical / methods Thioglycolates / analysis, chemical synthesis* |
| Chemical | |
Reg. No./Substance:
|
0/Peptides; 0/Polymers; 0/Thioglycolates; 0/alpha,beta-poly((2-hydroxyethyl)-aspartamide) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection of percolation phenomena in binary polar liquids by broadband dielectric spectroscopy.
Next Document: Atractylis gummifera L. poisoning: an ethnopharmacological review.