Document Detail


Synthesis and characterization of soybean-based hydrogels with an intrinsic activity on cell differentiation.
MedLine Citation:
PMID:  22616570     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The successful regeneration of large defects in traumatised and diseased tissues depends on the availability of biodegradable and bioactive biomaterials able to guide the tissue during its repair by offering both a physical support and a control of its biological mechanisms. Recently, a novel class of natural, biodegradable biomaterials has been obtained by the thermosetting of defatted soy curd. These biomaterials have been shown to regulate the activity of both tissue and inflammatory cells. Here, soybean-based hydrogels with different physico-chemical properties and bioactivity have been obtained with a relatively simple and highly reproducible processing method. The content of the different soy components (e.g. the isoflavones) was tuned varying the solvent system during the extraction procedure, while variations in the material crosslinking provided either loose hydrogels or a bioglue. The biomaterials obtained can be used as either bioadhesives or injectable formulations in regenerative medicine as they were shown to stimulate the synthesis of collagen by fibroblasts and the formation of mineralised bone noduli by osteoblasts.
Authors:
Steven Meikle; Guy Standen; Jonathan Salvage; Roberto Desantis; Luigi Nicolais; Luigi Ambrosio; Matteo Santin
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-23
Journal Detail:
Title:  Tissue engineering. Part A     Volume:  -     ISSN:  1937-335X     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466659     Medline TA:  Tissue Eng Part A     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Brighton, School of Pharmacy and Biomolecular Sciences, Brighton, United Kingdom; s.meikle@brighton.ac.uk.
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