| Synthesis and characterization of poly(dimer acid-brassylic acid) copolymer and poly(dimer acid-pentadecandioic acid) copolymer. | |
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MedLine Citation:
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PMID: 15150800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(dimer acid-brassylic acid) [P(DA-BA)] copolymers and poly(dimer acid-pentadecandioic acid) [P(DA-PA)] copolymers were prepared by melt polycondensation of the corresponding mixed anhydride prepolymers. The copolymers were characterized by Fourier transform infrared (FTIR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), wide angle x-ray powder-diffraction, and thermal gravimetric analysis (TGA). In vitro studies show that all the copolymers are degradable in phosphate buffer at 37 degrees C, and leaving an oily dimer acid residue after hydrolysis for the copolymer with high content of dimer acid. The release profiles of hydrophilic model drug, ciprofloxcin hydrochloride, from the copolymers, follow first-order release kinetics. All the preliminary results suggested that the copolymer might be potentially used as drug delivery devices. |
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Authors:
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Wen-xun Guo; Kai-xun Huang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biopolymers Volume: 74 ISSN: 0006-3525 ISO Abbreviation: Biopolymers Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-19 Completed Date: 2004-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372525 Medline TA: Biopolymers Country: United States |
Other Details:
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Languages: eng Pagination: 248-55 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley Periodicals, Inc. Biopolymers, 2004 |
Affiliation:
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Department of Chemistry, Huazhong University of Science and Technology, Wuhan, Hubei 430074, Peoples Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkanes
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chemistry* Anti-Infective Agents / pharmacokinetics Ciprofloxacin / pharmacokinetics Dicarboxylic Acids / chemistry* Fatty Acids / chemistry* Polymers / chemical synthesis*, pharmacokinetics Spectrophotometry, Infrared X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
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0/Alkanes; 0/Anti-Infective Agents; 0/Dicarboxylic Acids; 0/Fatty Acids; 0/Polymers; 0/pentadecanoic acid; 505-52-2/tridecanedioic acid; 85721-33-1/Ciprofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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