Document Detail

Synthesis and characterization of poly(L-lactic acid-co-ethylene oxide-co-aspartic acid) and its interaction with cells.
MedLine Citation:
PMID:  16555113     Owner:  NLM     Status:  MEDLINE    
Multiblock terpolymer of poly(L-lactic acid)/poly(ethylene oxide)/poly(L-aspartic acid), (PLLA/PEO/PAsp) was synthesized by ring opening polymerization of beta -benzyl L-aspartate N-carboxyanhydride, Asp(OBzl)-NCA with alpha-omega -hydroxy terminated triblock PLLA/PEO/PLLA copolymer. The resulting multiblock terpolymer was characterized by several techniques including Fourier transform infrared spectroscopy and differential scanning calorimetry.(1)H nuclear magnetic resonance spectra indicated the molar ratio of PLLA/PEO/PAsp (OBzl) to be 86/10/4. Thermal gravimetric analysis and environmental scanning electron microscopy data showed that PLLA/PEO/PAsp had crystalline and brittle structure. In order to improve its mechanical and physical properties, the terpolymer was blended with high molecular weight poly(L-lactic-co-glycolic acid) copolymer, PLGA(85/15) (M(w): 95000 gmol(-1)) in 25/75 and 50/50 mole ratios. The hydrolytical degradation properties of these polymers were studied. Degradation experiments were performed during a 48-day period in pH:7.4 phosphate-buffered saline (PBS) at 37 degrees C. The observed molecular weight losses were 91% and 67% for the 25/75 and 50/50 mixtures, respectively. In vitro attachment and growth of L929 mouse fibroblasts on these biopolymers were also investigated. Cell growth experiments indicated that the copolymer blend allowed the attachment and growth of cells.
Okşan Karal-Yilmaz; Nilhan Kayaman-Apohan; Zülal Misirli; Kemal Baysal; Bahattin M Baysal
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  17     ISSN:  0957-4530     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-23     Completed Date:  2006-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-27     Citation Subset:  IM    
TUBITAK, Research Institute for Genetic Engineering and Biotechnology, Gebze-Kocaeli, Turkey.
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MeSH Terms
Aspartic Acid / chemistry*
Biocompatible Materials / chemical synthesis*
Biodegradation, Environmental / drug effects
Cell Line
Cell Survival / drug effects
Lactic Acid / chemical synthesis*,  pharmacology*
Materials Testing
Microscopy, Electron, Scanning / methods
Models, Molecular
Polyglycolic Acid / chemical synthesis*,  pharmacology*
Polymers / chemical synthesis*,  pharmacology
Surface Properties
Tissue Engineering
Reg. No./Substance:
0/Biocompatible Materials; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 56-84-8/Aspartic Acid

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