| Synthesis and characterization of poly(L-lactic acid-co-ethylene oxide-co-aspartic acid) and its interaction with cells. | |
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MedLine Citation:
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PMID: 16555113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiblock terpolymer of poly(L-lactic acid)/poly(ethylene oxide)/poly(L-aspartic acid), (PLLA/PEO/PAsp) was synthesized by ring opening polymerization of beta -benzyl L-aspartate N-carboxyanhydride, Asp(OBzl)-NCA with alpha-omega -hydroxy terminated triblock PLLA/PEO/PLLA copolymer. The resulting multiblock terpolymer was characterized by several techniques including Fourier transform infrared spectroscopy and differential scanning calorimetry.(1)H nuclear magnetic resonance spectra indicated the molar ratio of PLLA/PEO/PAsp (OBzl) to be 86/10/4. Thermal gravimetric analysis and environmental scanning electron microscopy data showed that PLLA/PEO/PAsp had crystalline and brittle structure. In order to improve its mechanical and physical properties, the terpolymer was blended with high molecular weight poly(L-lactic-co-glycolic acid) copolymer, PLGA(85/15) (M(w): 95000 gmol(-1)) in 25/75 and 50/50 mole ratios. The hydrolytical degradation properties of these polymers were studied. Degradation experiments were performed during a 48-day period in pH:7.4 phosphate-buffered saline (PBS) at 37 degrees C. The observed molecular weight losses were 91% and 67% for the 25/75 and 50/50 mixtures, respectively. In vitro attachment and growth of L929 mouse fibroblasts on these biopolymers were also investigated. Cell growth experiments indicated that the copolymer blend allowed the attachment and growth of cells. |
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Authors:
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Okşan Karal-Yilmaz; Nilhan Kayaman-Apohan; Zülal Misirli; Kemal Baysal; Bahattin M Baysal |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 17 ISSN: 0957-4530 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-23 Completed Date: 2006-08-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 213-27 Citation Subset: IM |
Affiliation:
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TUBITAK, Research Institute for Genetic Engineering and Biotechnology, Gebze-Kocaeli, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspartic Acid / chemistry* Biocompatible Materials / chemical synthesis* Biodegradation, Environmental / drug effects Cell Line Cell Survival / drug effects Lactic Acid / chemical synthesis*, pharmacology* Materials Testing Mice Microscopy, Electron, Scanning / methods Models, Molecular Polyglycolic Acid / chemical synthesis*, pharmacology* Polymers / chemical synthesis*, pharmacology Surface Properties Temperature Tissue Engineering |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 56-84-8/Aspartic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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