Document Detail


Synthesis, characterization, and paclitaxel release from a biodegradable, elastomeric, poly(ester urethane)urea bearing phosphorylcholine groups for reduced thrombogenicity.
MedLine Citation:
PMID:  23035885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biodegradable polymers with high elasticity, low thrombogenicity, and drug loading capacity continue to be pursued for vascular engineering applications, including vascular grafts and stents. A biodegradable elastomeric polyurethane was designed as a candidate material for use as a drug-eluting stent coating, such that it was nonthrombogenic and could provide antiproliferative drug release to inhibit smooth muscle cell proliferation. A phosphorylcholine containing poly(ester urethane) urea (PEUU-PC) was synthesized by grafting aminated phosphorylcholine onto backbone carboxyl groups of a polyurethane (PEUU-COOH) synthesized from a soft segment blend of polycaprolactone and dimethylolpropionic acid, a hard segment of diisocyanatobutane and a putrescine chain extender. Poly(ester urethane) urea (PEUU) from a soft segment of polycaprolactone alone was employed as a control material. All of the synthesized polyurethanes showed high distensibility (>600%) and tensile strengths in the 20-35 MPa range. PEUU-PC experienced greater degradation than PEUU or PEUU-COOH in either a saline or lipase enzyme solution. PEUU-PC also exhibited markedly inhibited ovine blood platelet deposition compared with PEUU-COOH and PEUU. Paclitaxel loaded in all of the polymers during solvent casting continued to release for 5 d after a burst release in a 10% ethanol/PBS solution, which was utilized to increase the solubility of the releasate. Rat smooth muscle cell proliferation was significantly inhibited in 1 wk cell culture when releasate from the paclitaxel-loaded films was present. Based on these results, the synthesized PEUU-PC has promising functionality for use as a nonthrombogenic, drug eluting coating on metallic vascular stents and grafts.
Authors:
Yi Hong; Sang-Ho Ye; Anca L Pelinescu; William R Wagner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-18
Journal Detail:
Title:  Biomacromolecules     Volume:  13     ISSN:  1526-4602     ISO Abbreviation:  Biomacromolecules     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-06-05     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3686-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials
Blood Platelets
Cell Proliferation
Drug Carriers
Drug-Eluting Stents*
Elasticity
Elastomers / chemistry
Hydroxy Acids / chemistry
Myocytes, Smooth Muscle / physiology
Paclitaxel / administration & dosage*,  pharmacokinetics
Phosphorylcholine / chemistry*
Polyesters / chemistry*
Polymers
Propionates / chemistry
Rats
Sheep / blood
Tensile Strength
Vascular Grafting*
Grant Support
ID/Acronym/Agency:
P41 EB002027/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/2,2-bis(hydroxymethyl)-propionic acid; 0/Biocompatible Materials; 0/Drug Carriers; 0/Elastomers; 0/Hydroxy Acids; 0/Polyesters; 0/Polymers; 0/Propionates; 0/poly(ester urethane)urea; 107-73-3/Phosphorylcholine; 24980-41-4/polycaprolactone; 33069-62-4/Paclitaxel
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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