Document Detail


Synthesis and characterization of pH-responsive and folated nanoparticles based on self-assembled brush-like PLGA/PEG/AEMA copolymer with targeted cancer therapy properties: A comprehensive kinetic study.
MedLine Citation:
PMID:  22397922     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this study, a novel nanocarrier was synthesized based on methacrylated poly(lactic-co-glycolic acid) (mPLGA) as a lipophilic domain, acrylated methoxy poly(ethylene glycol) (aMPEG) as hydrophilic part and N-2-[(tert-butoxycarbonyl)amino] ethyl methacrylamide (Boc-AEMA) as pH-responsive segment. Radical polymerization of the above-mentioned three modified monomers produces amphiphilic brush-like copolymer. The protecting amine group (Boc) was selectively deprotected and the latter targeted copolymer was produced through the reaction of this copolymer with activated folic acid. Nanoprecipitation method was used to prepare quercetin-loaded nanoparticles. Dynamic light scattering (DLS) analysis showed that the produced nanoparticles had nanometric size (<100nm) and low polydispersity in size at different pHs. Higuchi and Korsmeyer-Peppas models were applied to evaluate release mechanisms and kinetics. Based on in-vitro degradation study, we found that the brush-like copolymer underwent a rapid weight loss in acidic pH.
Authors:
Sepideh Khoee; Reza Rahmatolahzadeh
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-22
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  -     ISSN:  1768-3254     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Affiliation:
Polymer Chemistry Department, School of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran.
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