| Synthesis and characterization of novel biotinylated biodegradable poly(ethylene glycol)-b-poly(carbonate-lactic acid) copolymers. | |
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MedLine Citation:
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PMID: 16701844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(ethylene glycol)-b-poly(5-benzyloxy-trimethylene carbonate-lactic acid) copolymers (PEG-b-P(BTMC-LA)) were synthesized by ring-opening polymerization of lactide and 5-benzyloxy trimethylene carbonate in the presence of mono-hydroxyl poly(ethylene glycol) with diethyl zinc as catalyst. They were further converted into deprotected copolymers with the pendant hydroxyl groups by hydrogenolysis in the presence of Pd(OH)2/C, and finally conjugated with biotin through the free hydroxyl groups. Gel permeation chromatography, Fourier transform infrared, differential scanning calorimetry and 1H nuclear magnetic resonance studies confirmed the copolymer structures and successful attachment of biotin to the copolymer. |
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Authors:
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Zhigang Xie; Huili Guan; Changhai Lü; Xuesi Chen; Xiabin Jing |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-23 |
Journal Detail:
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Title: Acta biomaterialia Volume: 1 ISSN: 1742-7061 ISO Abbreviation: - Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2006-05-16 Completed Date: 2006-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101233144 Medline TA: Acta Biomater Country: England |
Other Details:
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Languages: eng Pagination: 635-41 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants* Absorption Avidin / chemistry* Biocompatible Materials / chemistry* Biotin / chemistry* Biotinylation Materials Testing Molecular Conformation Polyesters / analysis, chemistry* Polyethylene Glycols / analysis, chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Polyesters; 0/Polyethylene Glycols; 0/poly(ethylene glycol)-block-poly(5-benzyloxy-trimethylene carbonate-lactic acid); 1405-69-2/Avidin; 58-85-5/Biotin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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